GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| UVM | cis | rs11190604 | 1 | rs10883511 | chr10:102299407 | SEC31B | chr10:102246403-102289636:- | -0.4 | -5.11 | 4.19E-6 | Palmitoleic acid (16:1n-7) plasma levels |
| UVM | cis | rs11190604 | 1 | rs10883512 | chr10:102308516 | SEC31B | chr10:102246403-102289636:- | -0.39 | -5.1 | 4.38E-6 | Palmitoleic acid (16:1n-7) plasma levels |
| UVM | cis | rs10935120 | 1 | rs10935120 | chr3:134233092 | ANAPC13 | chr3:134196547-134204865:- | -0.45 | -7.07 | 2.86E-9 | Height |
| UVM | cis | rs11190604 | 1 | rs1106565 | chr10:102211613 | SEC31B | chr10:102246403-102289636:- | -0.39 | -5.11 | 4.24E-6 | Palmitoleic acid (16:1n-7) plasma levels |
| UVM | cis | rs11079321 | 1 | rs11079321 | chr17:55747416 | COIL | chr17:55015563-55038411:- | -0.45 | -5.19 | 3.15E-6 | Coronary artery calcification |
| UVM | cis | rs9902453 | 1 | rs11080114 | chr17:28407287 | EFCAB5 | chr17:28256874-28435469:+ | -0.4 | -5.08 | 4.7E-6 | Coffee consumption (cups per day) |
| UVM | cis | rs1109114 | 1 | rs1109114 | chr5:148615946 | AFAP1L1 | chr5:148651401-148721365:+ | 0.56 | 4.92 | 8.19E-6 | Body mass index |
| UVM | cis | rs9876781 | 1 | rs1109227 | chr3:48479207 | TREX1 | chr3:48501186-48509043:+ | -0.39 | -5.09 | 4.48E-6 | Longevity |
| UVM | cis | rs4074493 | 1 | rs11122198 | chr1:231171139 | FAM89A | chr1:231154704-231175995:- | 0.52 | 4.6 | 2.55E-5 | Carotid plaque burden (smoking interaction) |
| UVM | cis | rs9876781 | 1 | rs11130170 | chr3:48449897 | TREX1 | chr3:48501186-48509043:+ | -0.39 | -5.06 | 5.03E-6 | Longevity |
| UVM | cis | rs9876781 | 1 | rs11130171 | chr3:48462461 | TREX1 | chr3:48501186-48509043:+ | -0.4 | -5.1 | 4.38E-6 | Longevity |
| UVM | cis | rs2564921 | 1 | rs11130338 | chr3:53120924 | RFT1 | chr3:53122503-53164470:- | -0.37 | -5.22 | 2.82E-6 | Height |
| UVM | cis | rs11148252 | 1 | rs11148252 | chr13:53009048 | NEK3 | chr13:52706780-52733996:- | 0.47 | 5.71 | 4.66E-7 | Lewy body disease |
| UVM | cis | rs2985684 | 1 | rs11157696 | chr14:50105746 | RPL36AL | chr14:50085407-50087349:- | -0.54 | -5.79 | 3.51E-7 | Carotid intima media thickness |
| UVM | cis | rs2239557 | 1 | rs11159067 | chr14:74637444 | LIN52 | chr14:74551656-74667117:+ | 0.44 | 5.65 | 5.92E-7 | Common traits (Other) |